Vitreoretinal Lymphoma

Vitreoretinal lymphoma (VRL) is a rare variant of primary central nervous system (PCNSL), mostly diffuse large B cell lymphoma, which affects the retina and/or vitreous with or without optic nerve involvement. The disease course aggressive. Up to 90% patients develop within one year. diagnosis VRL challenging due nonspecific chronic and relapsing uveitis made by anterior chamber tab aspirate biopsy. There no established treatment protocol for bilateral involvement CNS are suggestions use only intravitreal chemotherapy methotrexate rituximab. Alternatively, systemic high-dose MTX external beam radiotherapy used. Further studies needed prove confirm prophylactic therapy in preventing limited VRL.